Most Widely Used Antiviral API for Herpes Simplex and Varicella-Zoster Infections
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
Acyclovir (CAS 59277-89-3) is a synthetic acyclic guanosine analogue antiviral that is selectively phosphorylated by viral thymidine kinase (TK) and subsequently inhibits viral DNA polymerase, terminating viral DNA chain elongation. Active against herpes simplex virus types 1 and 2 (HSV-1, HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV), acyclovir is among the most widely manufactured antiviral APIs globally with high multi-decade production volumes.
Acyclovir API quality specifications require HPLC purity ≥99.0% (IP/BP/USP), strict guanine-related impurity control (guanine NMT 0.5%, 8-azaguanine NMT 0.2%), and specific particle size control for different dosage forms: standard grade (D90 50–150 µm) for tablet compression and micronised grade (D90 <20 µm) for topical cream and ophthalmic preparations. pH of 1% aqueous solution must fall within 10.5–11.5 per pharmacopeial specification.
Swapnroop has been supplying high-volume Acyclovir API from Aurangabad, Maharashtra, for over a decade to tablet and cream manufacturers across India and 25+ export markets. Our WHO-GMP certified facility maintains dedicated equipment for this high-tonnage API with full pharmacopeial compliance, consistent particle size control, and large inventory enabling rapid order fulfilment.
Acyclovir API is supplied in double-polyethylene-lined fiber drums of 25 kg net weight for bulk commercial supply, and 5 kg HDPE jars for smaller orders. Micronised grade is supplied in 5 kg triple-layer bags with anti-static inner lining. Storage at controlled temperature (15–25°C) with relative humidity <60%.
Get Bulk QuoteThe CAS number for Acyclovir is 59277-89-3. It is an acyclic nucleoside analogue antiviral listed on the WHO Essential Medicines List.
Yes. Swapnroop supplies both standard and micronised Acyclovir API grades. Micronised grade (D90 <20µm) is validated by laser diffraction and specifically used for 5% topical cream and ophthalmic formulations.
Acyclovir is effective against herpes simplex virus (HSV-1 and HSV-2), varicella-zoster virus (VZV, causing chickenpox and shingles), and Epstein-Barr virus (EBV). It requires activation by virus-encoded thymidine kinase.
Acyclovir API is available in IP, BP, and USP pharmacopeial grades in both standard and micronised forms, with HPLC purity ≥98.5% and full pharmacopeial analytical test documentation.
MOQ is 25 kg for standard commercial supply with 2–3 week lead time. High-volume orders (100 kg+) may be available from existing stock with shorter lead times. Contact us for pricing.
Swapnroop Drugs and Pharmaceuticals is a trusted Acyclovir API manufacturer and bulk supplier in Aurangabad, Maharashtra, serving pharmaceutical formulation companies across India and 25+ international markets. Our WHO-GMP certified facility provides consistent Acyclovir API supply with full pharmacopeial compliance, competitive pricing, and complete regulatory documentation for domestic and export programs.
As a Acyclovir API exporter from Maharashtra, India, Swapnroop supports pharmaceutical companies worldwide with DMF-grade documentation, Certificate of Analysis, MSDS, impurity profiles, and regulatory filing assistance for USFDA, EMA, and CDSCO submissions. Contact us for Acyclovir API pricing, samples, and sourcing support.