HCl Salt Form of Abacavir NRTI – Enhanced Solubility for HIV Formulations
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
Abacavir Hydrochloride (CAS 136470-78-5 as HCl salt) is the hydrochloride salt form of the carbocyclic nucleoside reverse transcriptase inhibitor Abacavir, used in select antiretroviral formulations where salt form selection affects dissolution profile, stability, and hygroscopicity compared to the free base. This form is evaluated in early-stage formulation development and for specific regulatory market requirements.
The hydrochloride salt of Abacavir exhibits distinct solid-state characteristics including different crystal morphology, solubility behaviour, and stability profile compared to Abacavir sulfate or free base. Formulators sourcing this form require rigorous polymorphic characterisation (XRPD, DSC) and particle size distribution data to ensure tablet uniformity and bioavailability equivalence.
Swapnroop supplies Abacavir Hydrochloride API with full pharmacopeial characterisation from our Aurangabad WHO-GMP facility. Our technical team provides salt-form-specific analytical data including XRPD patterns, DSC thermograms, and comparative dissolution profiles to support IND and ANDA filing requirements.
Abacavir Hydrochloride API is packaged in amber glass bottles (100g, 500g) for R&D quantities and triple-layer HDPE drums for commercial volumes, with desiccant and nitrogen purging to maintain stability during storage and international shipment.
Get Bulk QuoteAbacavir Hydrochloride shares the base CAS number 136470-78-5 with Abacavir base. It is the HCl salt form with distinct physicochemical properties compared to the sulfate salt.
The HCl and sulfate are different salt forms of Abacavir with varying aqueous solubility, hygroscopicity, and stability profiles. Selection depends on formulation compatibility, target pH environment, and regulatory precedent.
We provide XRPD diffractogram and DSC thermogram data confirming the consistent crystalline polymorphic form of Abacavir Hydrochloride with every commercial batch.
MOQ is 1 kg for sampling and 25 kg for commercial bulk orders. Custom pack sizes available for formulation development programs.
Yes. Swapnroop provides DMF-grade documentation for Abacavir Hydrochloride API suitable for ANDA Type II DMF filings with USFDA, including full analytical data packages and regulatory correspondence support.
Swapnroop Drugs and Pharmaceuticals is a trusted Abacavir Hydrochloride API manufacturer and bulk supplier in Aurangabad, Maharashtra, serving pharmaceutical formulation companies across India and 25+ international markets. Our WHO-GMP certified facility provides consistent Abacavir Hydrochloride API supply with full pharmacopeial compliance, competitive pricing, and complete regulatory documentation for domestic and export programs.
As a Abacavir Hydrochloride API exporter from Maharashtra, India, Swapnroop supports pharmaceutical companies worldwide with DMF-grade documentation, Certificate of Analysis, MSDS, impurity profiles, and regulatory filing assistance for USFDA, EMA, and CDSCO submissions. Contact us for Abacavir Hydrochloride API pricing, samples, and sourcing support.