Synthetic PTH Analogue for Osteoporosis – Anabolic Bone Formation Stimulator
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Identification | IR & HPLC compliant |
| Assay (HPLC) | 98.0% – 102.0% |
| Loss on Drying | NMT 1.0% |
| Residue on Ignition | NMT 0.2% |
| Heavy Metals | NMT 10 ppm |
| pH (1% Solution) | 2.0 – 4.0 |
| Individual Impurity | ≤ 0.5% |
| Total Impurities | ≤ 1.5% |
Abaloparatide (CAS 247062-33-5) is a synthetic 34-amino acid peptide analogue of parathyroid hormone-related protein (PTHrP) that selectively activates the PTH1 receptor to stimulate bone formation. Unlike teriparatide, abaloparatide exhibits a conformational bias toward the RG conformation of PTH1R, resulting in more anabolic bone-building activity with reduced hypercalcemia risk, making it a next-generation treatment for postmenopausal osteoporosis.
Peptide API sourcing requires stringent control of acetylation, deamidation, and oxidation-related impurities identified by RP-HPLC with UV detection at 220 nm. Abaloparatide's 34-residue sequence demands validated solid-phase peptide synthesis (SPPS) with Fmoc chemistry and rigorous purification to achieve ≥98% purity with less than 0.5% total impurities. Counter-ion (acetate) content and water content by KF must meet pharmacopeial specification.
Swapnroop supplies Abaloparatide API with high-purity peptide synthesis and analytical characterisation from our WHO-GMP facility in Aurangabad. Our documentation package includes HPLC purity profile, amino acid analysis (AAA), mass spectrometry (ESI-MS) molecular weight confirmation, and counter-ion content — the complete analytical suite required for subcutaneous injection formulation development and regulatory filing.
Abaloparatide peptide API is supplied in lyophilised powder form in sterile glass vials (10 mg, 50 mg, 100 mg) or bulk in foil-lined HDPE bottles under nitrogen blanket. Cold chain shipping (2–8°C or −20°C as per stability protocol) is mandatory for international peptide API export.
Get Bulk QuoteThe CAS number for Abaloparatide is 247062-33-5. It is a synthetic 34-amino acid PTHrP analogue peptide used for osteoporosis treatment.
Abaloparatide is an anabolic bone agent that activates PTH1R receptors, stimulating osteoblast-mediated new bone formation. Unlike antiresorptive agents, it directly builds new bone tissue, increasing BMD at the lumbar spine and hip.
Abaloparatide API is supplied at ≥97% purity by RP-HPLC with additional peptide mapping, amino acid composition, mass spectrometry confirmation, and impurity profiling (truncated sequences, oxidation products).
Abaloparatide peptide API must be stored at 2–8°C in sealed containers under inert atmosphere. Avoid freeze-thaw cycles. Shelf life is typically 18–24 months under recommended conditions.
Yes, we supply Abaloparatide API for Phase II/III clinical trials and NDA submissions with complete analytical documentation, batch records, and regulatory filing support.
Swapnroop Drugs and Pharmaceuticals is a trusted Abaloparatide API manufacturer and bulk supplier in Aurangabad, Maharashtra, serving pharmaceutical formulation companies across India and 25+ international markets. Our WHO-GMP certified facility provides consistent Abaloparatide API supply with full pharmacopeial compliance, competitive pricing, and complete regulatory documentation for domestic and export programs.
As a Abaloparatide API exporter from Maharashtra, India, Swapnroop supports pharmaceutical companies worldwide with DMF-grade documentation, Certificate of Analysis, MSDS, impurity profiles, and regulatory filing assistance for USFDA, EMA, and CDSCO submissions. Contact us for Abaloparatide API pricing, samples, and sourcing support.